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The results of this study show significant differences between individuals with and without selfreported chemical-related sensitivity ...
http://www.ehjournal.net/content/6/1/6
Environmental Health
Research Open Access
A cross-sectional study of self-reported chemical-related sensitivity
is associated with gene variants of drug-metabolizing enzymes
Eckart Schnakenberg*1, Karl-Rainer Fabig2, Martin Stanulla4, Nils Strobl3,
Michael Lustig3, Nathalie Fabig2 and Werner Schloot3
Address: 1Institute for Pharmacogenetic and Genetic Disposition, Ostpassage 7, D-30853 Langenhagen, Germany, 2Clinical Practice for Toxicology
and Environmental Medicine, Immenhoeven 19, D-22417 Hamburg, Germany, 3Center for Human Genetics and Genetic Counselling, University
of Bremen, Leobenerstr. ZHG, D-28359 Bremen, Germany and 4Children's Hospital, Pediatric Hematology and Oncology, Hannover Medical
School, Carl-Neuberg-Str. 1, D-30625 Hannover, Germany
Email: Eckart Schnakenberg* -
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; Karl-Rainer Fabig -
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; Martin Stanulla -
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;
Nils Strobl -
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; Michael Lustig -
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; Nathalie Fabig -
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;
Werner Schloot -
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* Corresponding author
Published: 10 February 2007
Environmental Health 2007, 6:6 doi:10.1186/1476-069X-6-6
Received: 6 March 2006
Accepted: 10 February 2007
This article is available from: http://www.ehjournal.net/content/6/1/6
© 2007 Schnakenberg et al; licensee BioMed Central Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0),
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Background: N-acetyltransferases (NAT) and glutathione S-transferases (GST) are involved inthe metabolism of several ubiquitous chemical substances leading to the activation and
detoxification of carcinogenic heterocyclic and aromatic amines. Since polymorphisms within these genes are described to influence the metabolism of ubiquitous chemicals, we conducted the present study to determine if individuals with self-reported chemical-related sensitivity differed from controls without self-reported chemical-related sensitivity with regard to the distribution of genotype frequencies of NAT2, GSTM1, GSTT1, and GSTP1 polymorphisms.
Methods: Out of 800 subjects who answered a questionnaire of ten items with regard to their
severity of chemical sensitivity 521 unrelated individuals agreed to participate in the study.
Subsequently, genetic variants of the NAT2, GSTM1, GSTT1, and GSTP1 genes were analyzed.
Results: The results show significant differences between individuals with and without selfreported chemical-related sensitivity with regard to the distribution of NAT2, GSTM1, and GSTT1 gene variants. Cases with self-reported chemical-related sensitivity were significantly more frequently NAT2 slow acetylators (controlled OR = 1.81, 95% CI = 1.27–2.59, P = 0.001). GSTM1 and GSTT1 genes were significantly more often homozygously deleted in those individuals reporting sensitivity to chemicals compared to controls (GSTM1: controlled OR 2.08, 95% CI = 1.46–2.96, P = 0.0001; GSTT1: controlled OR = 2.80, 95% CI = 1.65–4.75, P = 0.0001). Effects for GSTP1 gene variants were observed in conjunction with GSTM1, GSTT1 and NAT2 gene. Conclusion: The results from our study population show that individuals being slow acetylators and/or harbouring a homozygous GSTM1 and/or GSTT1 deletion reported chemical-related hypersensitivity more frequently.
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